在巴爾地摩，重案組緝毒小組正在一處住宅區展開毒品交易的搜查。而神通廣大的毒梟，才剛運用惡勢力幫助手下成功自一宗強暴謀殺案件中安然脫身。重案組警探麥諾提不甘見到歹徒逍遙法外，主動向辦案法官兼好友表示，這群惡徒才是十幾宗未破命案的真正兇手，但卻也因此讓自己面民撤換職務的下場。麥諾提的上司與同事在輿論平息後，全都無心再過問舊案，他卻仍決心和緝毒警探沙奇馬，攜手揪出販毒集團首腦艾文。

To safeguard their streets, the New Orleans Police Department boasts a dedicated team of homicide detectives, many of whom are natives of the legendary city. “Homicide Squad New Orleans” chronicles the harrowing work of this committed group of men and women united against the odds to protect their city and home. In each episode, the team will be faced with a new case and tasked with putting together the evidence to catch the perpetrator, find answers for the victims loved ones, and keep their community safe.